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Home >> Antibodies >> MMP2 Antibody / Matrix metalloproteinase 2

MMP2 Antibody / Matrix metalloproteinase 2 [clone 4D3] (V4430)

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  Catalog No Formulation Size Price (USD)  
Image V4430-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4430-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4430SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free MMP2 antibody (clone 4D3) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free MMP2 antibody (clone 4D3) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 4D3
Purity Protein A/G affinity
UniProt P08253
Localization Cytoplasm, Cell Surface
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This MMP2 antibody is available for research use only.
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Description

It recognizes a protein of 72kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV,V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.

Application Notes

Optimal dilution of the MMP2 antibody should be determined by the researcher.

Immunogen

A recombinant human MMP2 protein fragment (within amino acids 557-569) was used as the immunogen for the MMP2 antibody.

Storage

Aliquot the MMP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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