- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MFGE8 Antibody / Milk Fat Globule-Egf Factor 8 (R31046)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R31046 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Thimerosal |
| UniProt | Q08431 |
| Applications | Western blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This MFGE8 antibody is available for research use only. |
|
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Milk Fat Globule-Egf Factor 8, also called Lactadherin or SED1, is a protein which in humans is encoded by the MFGE8 gene. It is a secreted protein found in vertebrates, including mammals as well as birds. By fluorescence in situ hybridization, Collins et al.(1997) mapped the gene to chromosome 15q25. Hanayama et al.(2002) found that it is a factor that links apoptotic cells to phagocytes. MFGE8 specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine. When engaged by phospholipids, it bound to cells via its RGD motif. It bound particularly strongly to cells expressing alpha-V-beta-3 integrin. Bu et al.(2007) showed that MFGE8 was expressed in intestinal lamina propria macrophages in mice. Using a wound-healing assay, they showed that the protein promoted migration of intestinal epithelial cells through a PKC-epsilon (PRKCE)-dependent mechanism.
The stated application concentrations are suggested starting amounts. Titration of the MFGE8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the middle region of human MFGE8 (NGHEFDFIHDVNKKHK) was used as the immunogen for this MFGE8 antibody.
After reconstitution, the MFGE8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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