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Home >> Antibodies >> MDM2 Antibody

MDM2 Antibody (F42269)

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  Catalog No Formulation Size Price (USD)  
Image F42269-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F42269-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of MDM2 antibody and 293 lysate. Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.
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Western blot analysis of MDM2 antibody and 293 lysate. Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.
IHC analysis of FFPE human breast carcinoma tissue stained with the MDM2 antibody
Confocal immunofluorescent analysis of MDM2 antibody with HeLa cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used as a nuclear counterstain (blue).
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q00987
Applications Western blot : 1:1000
IHC (Paraffin) : 1:10-1:50
Immunofluorescence : 1:10-1:50
Limitations This MDM2 antibody is available for research use only.
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Description

MDM2 is a target of the transcription factor tumor protein p53. This protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.

Application Notes

Titration of the MDM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 141-176 from the human protein was used as the immunogen for this MDM2 antibody.

Storage

Aliquot the MDM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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