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- Email: info@nsjbio.com
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The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Optimal dilution of the MCAM antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 226-374) was used as the immunogen for the MCAM antibody.
Store the MCAM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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