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Home >> Antibodies >> MC1R Antibody

MC1R Antibody (R32755)

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  Catalog No Formulation Size Price (USD)  
Image R32755 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) rat PC12, 2) mouse Hepa1-6, 3) human HeLa and 4) human A375 cell lysate with MC1R antibody at 0.5ug/ml. Predicted molecular weight ~35 kDa.
Western blot testing of 1) rat PC12, 2) mouse Hepa1-6, 3) human HeLa and 4) human A375 cell lysate with MC1R antibody at 0.5ug/ml. Predicted molecular weight ~35 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
UniProt Q01726
Applications Western Blot : 0.5-1ug/ml
Limitations This MC1R antibody is available for research use only.
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Description

The Melanocortin 1 receptor (MC1R), mapped to 16q24.3, is also known as MSHR. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Application Notes

Optimal dilution of the MC1R antibody should be determined by the researcher.

Immunogen

Amino acids 290-317 (NAIIDPLIYAFHSQELRRTLKEVLTCSW) from the human protein were used as the immunogen for the MC1R antibody.

Storage

After reconstitution, the MC1R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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