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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Titration of the LOX antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 234-260 from the human protein was used as the immunogen for this LOX antibody.
Aliquot the LOX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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