- Tel: 858.663.9055
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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The LDHB gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.
Differences in protocols and secondary/substrate sensitivity may require the LDHB antibody to be titrated for optimal performance.
Amino acids E237-L334 from the human protein were used as the immunogen for the LDHB antibody.
After reconstitution, the LDHB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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