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Home >> Antibodies >> LATS1 Antibody

LATS1 Antibody (F50049)

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  Catalog No Formulation Size Price (USD)  
Image F50049-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F50049-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of LATS1 antibody and K562 lysate.
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Western blot analysis of LATS1 antibody and K562 lysate.
IHC analysis of FFPE human hepatocarcinoma tissue stained with the LATS1 antibody
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt O95835
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Limitations This LATS1 antibody is available for research use only.
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  • Applications : WB, IHC-P, Direct ELISA
    Reactivity : Human

Description

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Application Notes

Titration of the LATS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1-30 from the human protein was used as the immunogen for this LATS1 antibody.

Storage

Aliquot the LATS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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