• Tel: 858.663.9055
  • SeparatorEmail: info@nsjbio.com
  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Order
Home >> Antibodies >> K63-Linkage Specific Ubiquitin Antibody

K63-Linkage Specific Ubiquitin Antibody [clone IGC-21] (RQ5310)

NSJ bio Image Pdf Image
  Catalog No Formulation Size Price (USD)  
Image RQ5310 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
Microvalidated Rab Mono Image
Bulk quote request
Western blot testing of K63-linked Ub2 recombinant protein with K63-Linkage Specific Ubiquitin antibody.
Western blot testing of K63-linked Ub2 recombinant protein with K63-Linkage Specific Ubiquitin antibody.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name IGC-21
Purity Affinity purified
UniProt P0CG47
Applications Western blot : 1:500-1:2000
Limitations This K63-Linkage Specific Ubiquitin antibody is available for research use only.
Review this product on BioCompare and get a $20 Amazon gift card

Related Products

  • Applications : IHC-P
    Reactivity : Human
    Recrabbitmono
  • Applications : FACS, WB, IF, IHC-P
    Reactivity : Human
    Microvalidated
  • Applications : ELISA, WB, IHC-P
    Reactivity : Human
    Microvalidated
  • Applications : IHC-P, WB
    Reactivity : Human
  • Applications : FACS, IF, IHC-P, WB
    Reactivity : Human
    Rab Mono Image
  • Applications : IHC-P, WB
    Reactivity : Human
    Rab Mono Image
  • Applications : WB
    Reactivity : Human
    Rab Mono Image
  • Applications : WB, IHC-P
    Reactivity : Human, Mouse, Rat
  • Applications : WB, IHC-P
    Reactivity : Human, Mouse, Rat
  • Applications : WB, IHC-P
    Reactivity : Human, Mouse, Rat
  • Applications : IF, WB, IHC, ELISA
    Reactivity : Human
    Pred. Reactivity : Mouse, Rat, Bovine, Pig, Primate, Chicken, Drosophila, Yeast, C. elegans
  • Applications : WB, ELISA
    Reactivity : Human, Mouse, Rat
    Pred. Reactivity : Bovine, C. elegans, Chicken, Drosophila, Hamster, Pig, Primate, Rabbit, Xenopus

Description

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. [UniProt]

Application Notes

Optimal dilution of the K63-Linkage Specific Ubiquitin antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to Lys-63-linked Ubiquitin was used as the immunogen for the K63-Linkage Specific Ubiquitin antibody.

Storage

Store the K63-Linkage Specific Ubiquitin antibody at -20oC.

Related Products

   1.   View all K63-linkage Specific Ubiquitin antibodies

Cross
Bulk Quote Request Form
Name*:
Organization*:
Email*:
Phone Number*:
Catalog No.*:
Comments and Specifics(amount, formulation, etc.)*:
Validation code: Captchapackage Image


Can't read the image? click here to refresh.
    *required field

Your bulk quote request has been submitted successfully!

Please contact us if you have any questions.