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Home >> Antibodies >> IRF5 Antibody

IRF5 Antibody (R31332)

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Image R31332 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of IRF5 antibody and Lane 1: human placenta; 2: rat thymus; 3: (r) kidney; 4: (r) ovary tissue lysate. Expected/observed molecular weight ~57kDa.
Western blot testing of IRF5 antibody and Lane 1: human placenta; 2: rat thymus; 3: (r) kidney; 4: (r) ovary tissue lysate. Expected/observed molecular weight ~57kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q13568
Applications Western blot : 0.5-1ug/ml
Limitations This IRF5 antibody is available for research use only.
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Description

Interferon regulatory factor 5, also called SLEB10, is a protein that in humans is encoded by the IRF5 gene. This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan(W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. This gene is a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the IRF5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human Interferon regulatory factor 5 (EQFKELHHIWQSQQRLQ) was used as the immunogen for this IRF5 antibody (100% rat homology).

Storage

After reconstitution, the IRF5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Related Products

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