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- Tel: 858.663.9055
- Email: info@nsjbio.com
Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. IP3R is an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in the gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.
The stated application concentrations are suggested starting amounts. Titration of the IP3R antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human partial recombinant protein (AA 2411-2758) was used as the immunogen for this IP3R antibody.
After reconstitution, the IP3R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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