- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Interleukin-1 beta Antibody / IL1B [clone IL1B/463] (V4914)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
V4914-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 519 | |
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V4914-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 229 | |
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V4914SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 519 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | IL1B/463 |
| Purity | Protein A/G affinity |
| UniProt | P01584 |
| Localization | Cytoplasm, Extracellular (secreted) |
| Applications | ELISA (Order BSA-free format for coating) : Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Interleukin-1 beta antibody is available for research use only. |
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Recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of mAb IL1B/463 and IL1B/4649 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Optimal dilution of the Interleukin-1 beta antibody should be determined by the researcher.
Recombinant human IL1B protein was used as the immunogen for the Interleukin-1 beta antibody.
Aliquot the Interleukin-1 beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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