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Home >> Antibodies >> Integrin beta 3 Antibody / CD61 / ITGB3

Integrin beta 3 Antibody / CD61 / ITGB3 [clone ITGB3/1713] (V3264)

  Catalog No Formulation Size Price (USD)  
Image V3264-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3264-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3264SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Bulk quote request
IHC testing of FFPE human spleen tissue with Integrin beta 3 antibody (clone ITGB3/1713). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name ITGB3/1713
Purity Protein G affinity
UniProt P05106
Localization Cell surface, cytoplasmic
Applications Immunohistochemistry (Frozen & FFPE) : 1-2ug/ml for 30 min at RT
Limitations This Integrin beta 3 antibody is available for research use only.
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Description

Reacts with human Integrin beta 3, also called CD61. It associates with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Application Notes

Titration of the Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human recombinant protein used as the immunogen for the Integrin beta 3 antibody.

Storage

Store the Integrin beta 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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