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- Email: info@nsjbio.com
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The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
Titration of the Integrin beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Purified His-tagged protein fragment was used to produced this monoclonal Integrin beta 2/CD18 antibody.
Aliquot the Integrin beta 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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