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Home >> Antibodies >> INSM2 Antibody / Insulinoma Associated 2

INSM2 Antibody / Insulinoma Associated 2 [clone INSM2/4291] (V8752)

  Catalog No Formulation Size Price (USD)  
Image V8752-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8752-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8752SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using INSM2 antibody. These results demonstrate the foremost specificity of the INSM2/4291 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
IHC staining of FFPE human pancreas with INSM2 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free INSM2 antibody as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name INSM2/4291
Purity Protein G affinity chromatography
UniProt Q96T92
Localization Nuclear, cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This INSM2 antibody is available for research use only.
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Description

IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription. INSM2 may function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

Application Notes

Optimal dilution of the INSM2 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 432-540 from the human protein was used as the immunogen for the INSM2 antibody.

Storage

Store the INSM2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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