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IL3RA (Interleukin 3 receptor alpha), also called CD123 (Cluster of Differentiation 123), is a human gene. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor which is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3(IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5(IL5). The genomic structures of IL3RA and CSF2RA are very similar and share an additional exon encoding part of the C-terminal domain not found in other members of this gene family. As in human hematopoietic cells, IL3 and GMCSF competed for binding in fibroblasts expressing the cDNAs for IL3RA, CSF2RA, and the common beta subunit, indicating that different alpha subunits compete for a common beta subunit.
The stated application concentrations are suggested starting amounts. Titration of the IL3RA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the middle region of human IL3RA (QYDLYLNVANRRQQYEC) was used as the immunogen for this IL3RA antibody.
After reconstitution, the IL3RA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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