- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IKK alpha Antibody (R31535)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R31535 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| Gene ID | 1147 |
| Applications | Western blot : 0.5-1ug/ml IHC (FFPE) : 0.5-1ug/ml |
| Limitations | This IKK alpha antibody is available for research use only. |
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Inhibitor of nuclear factor kappa-B kinase subunit alpha, also known as conserved helix-loop-helix ubiquitous kinase (CHUK) or IKBKA, is a protein kinase that in humans is encoded by the CHUK gene. It is mapped to 10q24.31. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. IKK alpha is part of the IkB kinase complex that plays an important role in regulating the NF-kB transcription factor. IKK alpha also has many additional cellular targets, and is thought to function independently of the NF-kB pathway to regulate epidermal differentiation.
The stated application concentrations are suggested starting amounts. Titration of the IKK alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human partial recombinant protein (AA 411-745) was used as the immunogen for this IKK alpha antibody.
After reconstitution, the IKK alpha antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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