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Home >> Antibodies >> IGF2BP2 Antibody / IMP-2

IGF2BP2 Antibody / IMP-2 [clone PCRP-IGF2BP2-1F9] (V5017)

  Catalog No Formulation Size Price (USD)  
Image V5017-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5017-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5017SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated
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Analysis of a HuProt(TM) microarray containing more than 19,000 full-length human proteins using IGF2BP2 antibody (PCRP-IGF2BP2-1F9). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.
Flow cytometry testing of PFA-fixed human HeLa cells with IGF2BP2 antibody (clone PCRP-IGF2BP2-1F9) followed by goat anti-mouse IgG-CF488 (blue); Red = unstained cells.
SDS-PAGE analysis of purified, BSA-free IGF2BP2 antibody (clone PCRP-IGF2BP2-1F9) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG
Clone Name PCRP-IGF2BP2-1F9
Purity Protein A/G affinity
UniProt Q9Y6M1
Localization Nucleus
Applications Flow cytometry : 1-2ug/million cells
Limitations This IGF2BP2 antibody is available for research use only.
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Description

IGF2BP2 (Insulin-like growth factor 2 mRNA binding protein 2) is also known as IGF2 mRNA-binding protein 2, IMP-2 (IGF-II mRNA-binding protein 2), VICKZ family member 2 or hepatocellular carcinoma autoantigen p62 and is a 556 amino acid protein. IGF2BP2 is expressed in a variety of tissues including heart, placenta, skeletal muscle, pancreas, fetal liver, lung, kidney, thymus and gonadal cells. IGF2BP2 is an RNA binding protein which may be involved in the regulation of mRNA translation and may also function to control the spatial localization of target mRNAs. Antibodies against IGF2BP2 have been detected in patients with HCC (hepatocellular carcinoma), suggesting that IGF2BP2 may have a role in the pathogenesis of HCC. Defects in IGF2BP2 are thought to be associated with susceptibility to type two diabetes mellitus.

Application Notes

Optimal dilution of the IGF2BP2 antibody should be determined by the researcher.

Immunogen

Recombinant full-length human IGF2BP2 protein was used as the immunogen for the IGF2BP2 antibody.

Storage

Aliquot the IGF2BP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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