- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IFNAR1 Antibody / Interferon Receptor alpha [clone AF-9] (RQ4481)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ4481 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | AF-9 |
| Purity | Protein A affinity |
| UniProt | P17181 |
| Localization | Cell membrane, Cytoplasm |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This IFNAR1 antibody is available for research use only. |
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Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). [UniProt]
Optimal dilution of the IFNAR1 antibody should be determined by the researcher.
A synthetic peptide from human Interferon Receptor alpha was used as the immunogen for the IFNAR1 antibody.
Store the IFNAR1 antibody at -20oC.
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