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Home >> Antibodies >> IA1 Antibody / Insulinoma associated protein 1 / INSM1

IA1 Antibody / Insulinoma associated protein 1 / INSM1 [clone INSM1/7992R] (V4819)

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  Catalog No Formulation Size Price (USD)  
Image V4819-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4819-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4819SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human pancreas tissue with IA1 antibody (clone INSM1/7992R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human pancreas tissue with IA1 antibody (clone INSM1/7992R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name INSM1/7992R
Purity Protein A/G affinity
UniProt Q01101
Localization Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This IA1 antibody is available for research use only.
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Description

Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95% of lung small cell carcinoma and 91% of lung large cell neuroendocrine carcinoma, compared with 75% and 78% with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100% of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3% of adenocarcinomas and 4% of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

Application Notes

Optimal dilution of the IA1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 1-300) from the human protein was used as the immunogen for the IA1 antibody.

Storage

Aliquot the IA1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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