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Home >> Antibodies >> HSD11B1 Antibody

HSD11B1 Antibody (R30441)

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  Catalog No Formulation Size Price (USD)  
Image R30441 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of HSD11B1 antibody and Lane 1: rat liver; 2: rat testis; 3: SMMC-7721; 4: Raji; 5: SW620. Predicted molecular weight: ~32kDa.
Western blot testing of HSD11B1 antibody and Lane 1: rat liver; 2: rat testis; 3: SMMC-7721; 4: Raji; 5: SW620. Predicted molecular weight: ~32kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P28845
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This HSD11B1 antibody is available for research use only.
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    Reactivity : Human
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    Reactivity : Mouse
    Pred. Reactivity : Rat

Description

11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al.(1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al.(2000) mapped the HSD11B1 gene to 1q32-q41.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the HSD11B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of human HSD11B1 (MAYYYYSANEEFRPEMLQ) was used as the immunogen for this HSD11B1 antibody.

Storage

After reconstitution, the HSD11B1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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