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Home >> Antibodies >> HLA-A Antibody (MHC I)

HLA-A Antibody (MHC I) [clone 108-2C5] (V2571)

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  Catalog No Formulation Size Price (USD)  
Image V2571-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V2571-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V2571SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Flow cytometry testing of human Raji cells with HLA-A antibody (clone 108-2C5); Red=isotype control, Blue= HLA-A antibody.
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Flow cytometry testing of human Raji cells with HLA-A antibody (clone 108-2C5); Red=isotype control, Blue= HLA-A antibody.
SDS-PAGE analysis of purified, BSA-free HLA-A antibody (clone 108-2C5) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 108-2C5
Purity Protein G affinity chromatography
UniProt P30443
Localization Cell surface
Applications Flow cytometry : 1-2ug/10^6 cells
Immunofluorescence : 1-2ug/ml
Limitations This HLA-A antibody is available for research use only.
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Description

HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This mAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and Aw33). Its epitope maps between aa65-to-aa80 of the alpha1 domain of the HLA-A. This mAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the alpha1 domain was demonstrated in the formation of an intralocus HLA-A determinant.

Application Notes

Optimal dilution of the HLA-A antibody should be determined by the researcher.

Immunogen

Normal human peripheral blood lymphocytes were used as the immunogen for the HLA-A antibody.

Storage

Store the HLA-A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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