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Home >> Antibodies >> HIV Type-1 p24 Antibody

HIV Type-1 p24 Antibody [clone HIV1-24/661] (V2344)

  Catalog No Formulation Size Price (USD)  
V2344-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 329

V2344-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 129

V2344SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 359
Species Reactivity Human. Other species not known.
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name HIV1-24/661
Purity Protein G affinity chromatography
Buffer 1X PBS, pH 7.4
Gene ID 155348
Localization Membrane
Applications ELISA : order BSA-free format for coating
Immunocytochemistry (Acetone or paraformaldehyde fixed) : 0.5-1ug/ml for 30 min
Immunofluorescence : 0.5-1ug/ml
Limitations This HIV type-1 p24 antibody is available for research use only.

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Description

Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

Application Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the HIV Type-1 p24 antibody to be titered up or down for optimal performance.

Immunogen

Recombinant HIV-1 Gag p24 protein was used as the immunogen for this antibody.

Storage

Store the HIV Type-1 p24 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Alternate Names

Capsid protein p24; Human immunodeficiency virus type 1 p24; HIV1gp1; HIV-1 Gag p24

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