- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HIF1A Antibody (F50745)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F50745-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F50745-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Predicted Reactivity | Rat, Bovine |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Purified |
| UniProt | Q16665 |
| Localization | Nuclear, possible cytoplasmic |
| Applications | Western blot : 1:1000 IHC (Paraffin) : 1:50-1:100 Immunofluorescence : 1:10-1:50 Flow Cytometry : 1:10-1:50 |
| Limitations | This HIF1A antibody is available for research use only. |
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HIF1A functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. [UniProt]
Titration of the HIF1A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 519-547 from the human protein was used as the immunogen for this HIF1A antibody.
Aliquot the HIF1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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