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Home >> Antibodies >> GDF8 Antibody / Myostatin

GDF8 Antibody / Myostatin (RQ6108)

  Catalog No Formulation Size Price (USD)  
Image RQ6108 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) human Caco-2, 2) rat skeletal muscle and 3) mouse skeletal muscle with GDF8 antibody. Predicted molecular weight ~42 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt O14793
Applications Western blot : 1-2ug/ml
Limitations This GDF8 antibody is available for research use only.
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  • Applications : IHC, WB, ELISA
    Reactivity : Human, Mouse
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Description

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.

Application Notes

Optimal dilution of the GDF8 antibody should be determined by the researcher.

Immunogen

Amino acids SGECEFVFLQKYPH from the human protein were used as the immunogen for the GDF8 antibody.

Storage

After reconstitution, the GDF8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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