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Home >> Antibodies >> GAD67 Antibody

GAD67 Antibody (R31597)

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  Catalog No Formulation Size Price (USD)  
Image R31597 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of GAD67 antibody and Lane 1: rat testis; 2: mouse brain; 3: human MCF7 lysate. Predicted/observed molecular weight ~67 kDa
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Western blot testing of GAD67 antibody and Lane 1: rat testis; 2: mouse brain; 3: human MCF7 lysate. Predicted/observed molecular weight ~67 kDa
Western blot testing of GAD67 antibody and recombinant human protein (0.5ng)
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Gene ID 2571
Applications Western blot : 0.5-1ug/ml
Limitations This GAD67 antibody is available for research use only.
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Description

Glutamate decarboxylase 1 (GAD67), also known as GAD1, is a human gene. This gene encodes one of several forms of glutamic acid decarboxylase identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this GAD67 has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. It may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the GAD67 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human partial recombinant protein (AA 14-122) was used as the immunogen for this GAD67 antibody.

Storage

After reconstitution, the GAD67 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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