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Home >> Antibodies >> Frataxin Antibody / FXN

Frataxin Antibody / FXN [clone FDAX-1] (V3997)

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  Catalog No Formulation Size Price (USD)  
Image V3997-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3997-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3997SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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V3997IHC-7ML Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* 7 ml 519
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Western blot testing of Fascin antibody and human HepG2 cell lysate (clone FDAX-1). Expected molecular weight: ~23 kDa (full length), ~14 kDa (mature).
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Western blot testing of Fascin antibody and human HepG2 cell lysate (clone FDAX-1). Expected molecular weight: ~23 kDa (full length), ~14 kDa (mature).
IHC testing of FFPE human pancreas with Frataxin antibody (clone FDAX-1). Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name FDAX-1
Purity Protein G affinity chromatography
UniProt Q16595
Localization Cytoplasmic
Applications Western blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Prediluted IHC only format : incubate for 30 min at RT (1)
Limitations This Frataxin antibody is available for research use only.
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Description

Reduced expression of frataxin is the cause of Friedreich's ataxia (FRDA), a lethal neurodegenerative disease. The reduction in frataxin gene expression may be attributable from either the silencing of transcription of the frataxin gene because of epigenetic modifications in the chromosomal entity or from the inability of splicing the expanded GAA repeats in the first intron of the pre-mRNA as seen in bacteria and human cells or both. The expansion of intronic trinucleotide repeat GAA results in Friedreich's ataxia. [Wiki]

Application Notes

Optimal dilution of the Frataxin antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

Amino acids 57-210 from the human protein were used as the immunogen for this Frataxin antibody.

Storage

Store the Frataxin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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