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Home >> Antibodies >> FLI1 Antibody

FLI1 Antibody [clone FLVI1-1] (V7218)

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  Catalog No Formulation Size Price (USD)  
Image V7218-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7218-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7218SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot testing of 1) ThP1 and 2) Raji cell lysate with FLI1 antibody (clone FLVI1-1). Predicted molecular weight ~50 kDa.
Western blot testing of 1) ThP1 and 2) Raji cell lysate with FLI1 antibody (clone FLVI1-1). Predicted molecular weight ~50 kDa.
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name FLVI1-1
Purity Protein G affinity chromatography
Buffer 1X PBS, pH 7.4
Gene ID 2313
Localization Nuclear
Applications Western blot : 1-2ug/ml
Limitations This FLI1 antibody is available for research use only.
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Description

Friend leukemia integration 1 is a member of the ETS family of DNA binding transcription factors that is involved in cellular proliferation and tumorigenesis. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.

Application Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FLI1 antibody to be titered up or down for optimal performance.

Immunogen

Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.

Storage

Store the FLI1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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