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Home >> Antibodies >> Factor I Antibody / CFI

Factor I Antibody / CFI (R32399)

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  Catalog No Formulation Size Price (USD)  
Image R32399 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) rat liver and 2) human HeLa lysate with Factor I antibody. Expected molecular weight: 66 kDa (unmodified), 88 kDa (fully glycosylated), 50/38 kDa (fully glycosylated heavy/light chain).
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Western blot testing of 1) rat liver and 2) human HeLa lysate with Factor I antibody. Expected molecular weight: 66 kDa (unmodified), 88 kDa (fully glycosylated), 50/38 kDa (fully glycosylated heavy/light chain).
Flow cytometry testing of human HepG2 cells with Factor I antibody at 1ug/10^6 cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Factor I antibody.
Flow cytometry testing of human U-87 MG cells with Factor I antibody at 1ug/10^6 cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Factor I antibody.
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P05156
Applications Western blot : 0.1-0.5ug/ml
Flow Cytometry : 1-3ug/10^6 cells
Limitations This Factor I antibody is available for research use only.
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Description

Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

Immunogen

Amino acids K19-D220 were used as the immunogen for the Factor I antibody.

Storage

After reconstitution, the Factor I antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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