- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Estrogen Receptor Antibody (alpha) (R31605)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R31605 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| Gene ID | 2099 |
| Localization | Nuclear |
| Applications | Western blot : 0.5-1ug/ml IHC (FFPE) : 0.5-1ug/ml |
| Limitations | This Estrogen Receptor antibody is available for research use only. |
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Estrogen receptor alpha (ERa), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear protein that is activated by the sex hormone estrogen. ERs are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ERa is encoded by the gene ESR1. It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2/beta. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.
The stated application concentrations are suggested starting amounts. Titration of the Estrogen Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human ERa partial recombinant protein (AA 425-595) was used as the immunogen for this Estrogen Receptor antibody.
After reconstitution, the Estrogen Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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