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Home >> Antibodies >> EAG1 Antibody / KCNH1

EAG1 Antibody / KCNH1 (RQ7297)

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  Catalog No Formulation Size Price (USD)  
Image RQ7297 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) human U-87 MG, 2) human SH-SY5Y, 3) human HeLa, 4) human MCF7, 5) rat brain and 6) rat C6 cell lysate with EAG1 antibody. Predicted molecular weight ~111 kDa (may be observed larger than predicted due to glycosylation).
Western blot testing of 1) human U-87 MG, 2) human SH-SY5Y, 3) human HeLa, 4) human MCF7, 5) rat brain and 6) rat C6 cell lysate with EAG1 antibody. Predicted molecular weight ~111 kDa (may be observed larger than predicted due to glycosylation).
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt O95259
Applications Western blot : 0.5-1ug/ml
Limitations This EAG1 antibody is available for research use only.
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Description

Potassium voltage-gated channel subfamily H member 1, also called Ether-a-go-go potassium channel 1 (h-eag, EAG1) is a protein that in humans is encoded by the KCNH1 gene. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Application Notes

Optimal dilution of the EAG1 antibody should be determined by the researcher.

Immunogen

Amino acids QDRSPILAEVKHSFYPC were used as the immunogen for the EAG1 antibody.

Storage

After reconstitution, the EAG1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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