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Home >> Antibodies >> DR5 Antibody

DR5 Antibody [clone ABFC-20] (RQ4711)

  Catalog No Formulation Size Price (USD)  
Image RQ4711 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
Microvalidated Rab Mono Image
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Western blot testing of human HeLa cell lysate with DR5 antibody. Expected molecular weight: ~40 kDa (mature form) and ~48 kDa (precursor). This protein may also be visualized at ~60 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name ABFC-20
Purity Affinity purified
UniProt O14763
Applications Western blot : 1:1000-1:5000
Limitations This DR5 antibody is available for research use only.
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Description

The protein encoded by the TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. Death receptor 5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [RefSeq]

Application Notes

Optimal dilution of the DR5 antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human DR5 / TNFRSF10B was used as the immunogen for the DR5 antibody.

Storage

Store the DR5 antibody at -20oC.

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