- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
DPYD Antibody (R30854)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R30854 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | Q12882 |
| Applications | Western blot : 0.5-1ug/ml |
| Limitations | This DPYD antibody is available for research use only. |
|
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Dihydropyrimidine Dehydrogenase, also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the gene was mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the gene is mapped to 1p22. The highest level of DPYD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity could be detected in erythrocytes. The activity of DPYD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.
The stated application concentrations are suggested starting amounts. Titration of the DPYD antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 33-52 (AKKLDKKHWKRNPDKNCFNC-human) were used as the immunogen for this DPYD antibody.
After reconstitution, the DPYD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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