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  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Home >> Antibodies >> DC-SIGN Antibody

DC-SIGN Antibody (N1090)

  Catalog No Formulation Size Price (USD)  
N1090-100UG 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 275

N1090-25UG 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 25 ug 129
Western blot testing of human samples with DC-SIGN antibody at 2ug/ml. Predicted molecular weight ~46 kDa.
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Protein A purified antibody
Buffer 1X PBS, pH 7.4
Gene ID 30835
Applications Western blot : 2-5ug/ml
Limitations This DC-SIGN antibody is available for research use only.
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Description

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.

Application Notes

Provided assay concentrations are suggestions only, DC-SIGN antibody titration may be required for optimal results.

Immunogen

A recombinant protein fragment from human DC-SIGN was used as the immunogen for this antibody.

Storage

Aliquot the DC-SIGN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

CD209 antibody

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