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Home >> Antibodies >> Cytokeratin 6 Antibody

Cytokeratin 6 Antibody [clone KRT6/1702] (V3301)

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  Catalog No Formulation Size Price (USD)  
Image V3301-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3301-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3301SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC testing of FFPE human bladder carcinoma with Cytokeratin 6 antibody (clone KRT6/1702). Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.
IHC testing of FFPE human bladder carcinoma with Cytokeratin 6 antibody (clone KRT6/1702). Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a, kappa
Clone Name KRT6/1702
Purity Protein G affinity chromatography
UniProt P02538
Localization Cytoplasmic
Applications Immunohistochemistry (FFPE) : 0.1-0.2ug/ml for 30 min at RT
Limitations This Cytokeratin 6 antibody is available for research use only.
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Description

This mAb recognizes a protein of 56kDa, identified as Cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Application Notes

Optimal dilution of the Cytokeratin 6 antibody should be determined by the researcher.

Immunogen

Recombinant human CK6 protein was used as the immunogen for the Cytokeratin 6 antibody.

Storage

Store the Cytokeratin 6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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