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Chemokine CXC Motif Receptor 1, also known as IL8R, is the receptor for IL8. Morris et al.(1992) mapped the gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Binding of IL-8 to its receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. CXCR1 binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
The stated application concentrations are suggested starting amounts. Titration of the CXCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminus of human Chemokine CXC Motif Receptor 1 (DEDYSPCMLETETLN) was used as the immunogen for this CXCR1 antibody.
After reconstitution, the CXCR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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