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Home >> Antibodies >> CSB Antibody / Cockayne Syndrome B

CSB Antibody / Cockayne Syndrome B (R32528)

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  Catalog No Formulation Size Price (USD)  
Image R32528 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) HeLa, 2) A431 and 3) SiHa cell lysate with CSB antibody at 0.5ug/ml. Predicted/observed molecular weight: ~168 kDa.
Western blot testing of human 1) HeLa, 2) A431 and 3) SiHa cell lysate with CSB antibody at 0.5ug/ml. Predicted/observed molecular weight: ~168 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt Q03468
Localization Nuclear
Applications Western blot : 0.5-1ug/ml
Limitations This CSB antibody is available for research use only.
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Description

DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.

Application Notes

Differences in protocols and secondary/substrate sensitivity may require the CSB antibody to be titrated for optimal performance.

Immunogen

Amino acids 160-205 (QAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVK) from the human protein were used as the immunogen for the CSB antibody.

Storage

After reconstitution, the CSB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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