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Home >> Antibodies >> Complement Factor B Antibody / CFB

Complement Factor B Antibody / CFB (R32391)

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  Catalog No Formulation Size Price (USD)  
Image R32391 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) A549, 2) 293 and 3) HeLa cell lysate with Complement Factor B antibody. Expected/observed molecular weight ~86 kDa.
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Western blot testing of human 1) A549, 2) 293 and 3) HeLa cell lysate with Complement Factor B antibody. Expected/observed molecular weight ~86 kDa.
IHC testing of FFPE human lung cancer tissue with Complement Factor B antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to testing.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P00751
Localization Cytoplasmic
Applications Western blot : 0.1-0.5ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Complement Factor B antibody is available for research use only.
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Description

Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Application Notes

Optimal dilution of the Complement Factor B antibody should be determined by the researcher.

Immunogen

Amino acids E518-L764 from the human protein were used as the immunogen for the Complement Factor B antibody.

Storage

After reconstitution, the Complement Factor B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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