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- Email: info@nsjbio.com
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Collagen type 2 alpha 1, also known as COL2A1, is a human gene which is the major collagen synthesized by chondrocytes. COL2A1 is mapped to 12q13.11. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
The stated application concentrations are suggested starting amounts. Titration of the Collagen 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminus of human COL2A1 (AFAGLGPREKGPDPLQYMRA) was used as the immunogen for this Collagen 2 antibody.
After reconstitution, the Collagen 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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