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Home >> Antibodies >> CNN1 Antibody / Calponin 1

CNN1 Antibody / Calponin 1 [clone rCNN1/6918] (V4585)

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  Catalog No Formulation Size Price (USD)  
Image V4585-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4585-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4585SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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IHC staining of FFPE human uterus tissue with CNN1 antibody (clone rCNN1/6918). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human uterus tissue with CNN1 antibody (clone rCNN1/6918). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rCNN1/6918
Purity Protein A/G affinity
UniProt P51911
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This CNN1 antibody is available for research use only.
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Description

Multiple isoelectric variants of calponin have been identified, however only two molecular weight isoforms exist; a 34kDa form and a 29kDa form. Expression of the 29kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. In Western blotting, this mAb reacts with only the 34kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin and tropomyosin binding protein, which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.

Application Notes

Optimal dilution of the CNN1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 197-297) from the human protein was used as the immunogen for the CNN1 antibody.

Storage

Aliquot the CNN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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