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Home >> Antibodies >> CLIP Antibody

CLIP Antibody [clone CLIP/1133] (V3036)

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  Catalog No Formulation Size Price (USD)  
Image V3036-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3036-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3036SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot analysis of Raji cell lysate using CLIP antibody (CLIP/1133). Expected molecular weight: 33-43 kDa.
Western blot analysis of Raji cell lysate using CLIP antibody (CLIP/1133). Expected molecular weight: 33-43 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CLIP/1133
Purity Protein G affinity chromatography
UniProt P04233
Localization Cell surface and paranuclear globular
Applications Western blot : 1-2ug/ml
Limitations This CLIP antibody is available for research use only.
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Description

Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Application Notes

Optimal dilution of the CLIP antibody should be determined by the researcher.

Immunogen

Recombinant full-length human protein was used as the immunogen for the CLIP antibody.

Storage

Store the CLIP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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