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Home >> Antibodies >> CD80 Antibody

CD80 Antibody (R30434)

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  Catalog No Formulation Size Price (USD)  
Image R30434 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of CD80 antibody at 0.5ug/ml with rat thymus lysate; Expected molecular weight: 34-75 kDa depending on the level of glycosylation.
Western blot testing of CD80 antibody at 0.5ug/ml with rat thymus lysate; Expected molecular weight: 34-75 kDa depending on the level of glycosylation.
Availability 1-3 business days
Species Reactivity Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt O55202
Localization Cytoplasmic, membranous
Applications Western blot : 0.5-1ug/ml
Limitations This CD80 antibody is available for research use only.
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Description

Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al.(1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the CD80 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of rat CD80 (DAHVSQNFTWEKPPEDPPD) was used as the immunogen for this CD80 antibody.

Storage

After reconstitution, the CD80 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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