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Home >> Antibodies >> CD80 Antibody / B7-1

CD80 Antibody / B7-1 [clone C80/1608] (V3297)

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  Catalog No Formulation Size Price (USD)  
Image V3297-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3297-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3297SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free CD80 antibody (clone C80/1608) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free CD80 antibody (clone C80/1608) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name C80/1608
Purity Protein G affinity chromatography
UniProt P33681
Localization Cytoplasmic, membranous
Applications ELISA (order BSA/sodium azide-free format for coating) :
Limitations This CD80 antibody is available for research use only.
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Description

T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

Application Notes

Optimal dilution of the CD80 antibody should be determined by the researcher.

Immunogen

Recombinant human protein used as the immunogen for the CD80 antibody.

Storage

Store the CD80 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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