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Home >> Antibodies >> Cd59 Antibody

Cd59 Antibody (RQ4057)

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  Catalog No Formulation Size Price (USD)  
Image RQ4057 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of rat 1) liver, 2) kidney, 3) spleen and 4) brain lysate with Cd59 antibody at 0.5ug/ml. Predicted molecular weight ~14 kDa (unmodified), 18-20 kDa (glycosylated).
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Western blot testing of rat 1) liver, 2) kidney, 3) spleen and 4) brain lysate with Cd59 antibody at 0.5ug/ml. Predicted molecular weight ~14 kDa (unmodified), 18-20 kDa (glycosylated).
IHC testing of FFPE mouse spleen tissue with Cd59 antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
IHC testing of FFPE mouse thymus tissue with Cd59 antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
Availability 1-3 business days
Species Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt O55186
Localization Plasma membrane, cytoplasm
Applications Western Blot : 0.5-1ug/ml
IHC (FFPE) : 1-2ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This Cd59 antibody is available for research use only.
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Description

CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Application Notes

Optimal dilution of the Cd59 antibody should be determined by the researcher.

Immunogen

A recombinant mouse partial protein corresponding to amino acids L24-S96 was used as the immunogen for the Cd59 antibody.

Storage

After reconstitution, the Cd59 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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