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Home >> Antibodies >> CD46 Antibody

CD46 Antibody [clone 122.2] (V2190)

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  Catalog No Formulation Size Price (USD)  
Image V2190-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V2190-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V2190SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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CD46 antibody 122.2 flow cytometry
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FACS staining of human PBMC using CD46 antibody (clone 122.2).
SDS-PAGE Analysis of Purified, BSA-Free CD46 Antibody (clone 122.2). Confirmation of Integrity and Purity of the Antibody.
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 122.2
Purity Protein G affinity chromatography
Buffer 1X PBS, pH 7.4
Gene ID 4179
Localization Cell surface
Applications Functional studies (order BSA/sodium azide-free format) :
Flow cytometry : 1-2ug/10^6 cells
Immunofluorescence : 1-2ug/ml
Limitations This CD46 antibody is available for research use only.
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Description

CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Application Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD46 antibody to be titered up or down for optimal performance.

Immunogen

Recombinant human protein was used as the immunogen for this CD46 antibody.

Storage

Store the CD46 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Alternate Names

AHUS2; CD46 antigen complement regulatory protein; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen, CD46 antibody

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