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Home >> Antibodies >> CD269 Antibody / BCMA / TNFRSF17

CD269 Antibody / BCMA / TNFRSF17 [clone CD269/8508R] (V4422)

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  Catalog No Formulation Size Price (USD)  
Image V4422-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4422-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4422SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human prostate tissue with CD269 antibody (clone CD269/8508R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human prostate tissue with CD269 antibody (clone CD269/8508R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free CD269 antibody (clone CD269/8508R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name CD269/8508R
Purity Protein A/G affinity
UniProt Q02223
Localization Cell surface
Applications ELISA (Order BSA-free format for coating) :
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This CD269 antibody is available for research use only.
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Description

The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

Application Notes

Optimal dilution of the CD269 antibody should be determined by the researcher.

Immunogen

A recombinant human CD269 protein fragment (within amino acids 1-184) was used as the immunogen for the CD269 antibody.

Storage

Aliquot the CD269 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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