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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recognizes a glycoprotein of 110kDa, identified as CD26 (Workshop VI; Code: N-L039). It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this mAb reacts with only glycosylated CD26, but not with the deglycosylated form. It does not prevent ADA binding to CD26.
Optimal dilution of the CD26 antibody should be determined by the researcher.
A human T cell clone was used as the immunogen for the CD26 antibody.
Store the CD26 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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