- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CCND1 Antibody (F52187)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F52187-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F52187-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
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| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Predicted Reactivity | Bovine |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P24385 |
| Applications | Western blot : 1:1000 |
| Limitations | This CCND1 antibody is available for research use only. |
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Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 264-292 from the human protein was used as the immunogen for this CCND1 antibody.
Aliquot the CCND1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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