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Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is also called CCL3, LD78. The cDNA for CCL3 predicts a mature peptide of 69 amino acids with a molecular mass of 7,889 daltons. CCL3 is a member of a newly identified superfamily of small inducible proteins involved in inflammatory responses, wound healing and tumorigenesis. CCL3 is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. It constitutes an important second signal for mast cell degranulation in the conjunctiva in vivo and consequently for acute-phase disease.
The stated application concentrations are suggested starting amounts. Titration of the CCL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Rat partial recombinant protein (AA 24-92) was used as the immunogen for this CCL3 antibody.
After reconstitution, the CCL3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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