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Home >> Antibodies >> CASR Antibody / Calcium Sensing Receptor

CASR Antibody / Calcium Sensing Receptor [clone 11E9.] (RQ4484)

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  Catalog No Formulation Size Price (USD)  
Image RQ4484 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) HeLa, 2) A549, 3) 22RV1, 4) HepG2 and 5) Caco-2 lysate with CASR antibody at 0.5ug/ml. Predicted molecular weight ~121 kDa, but is routinely observed at up to ~160 kDa.
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Western blot testing of human 1) HeLa, 2) A549, 3) 22RV1, 4) HepG2 and 5) Caco-2 lysate with CASR antibody at 0.5ug/ml. Predicted molecular weight ~121 kDa, but is routinely observed at up to ~160 kDa.
Flow cytometry testing of mouse Neuro-2a cells with CASR antibody at 1ug/10^6 cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= CASR antibody.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Clone Name 11E9.
Purity Protein G affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P41180
Localization Cell membrane
Applications Western blot : 0.5-1ug/ml (human)
Flow Cytometry : 1-3ug/1x10^6 cells (mouse)
Limitations This CASR antibody is available for research use only.
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Description

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Application Notes

Optimal dilution of the CASR antibody should be determined by the researcher.

Immunogen

Human CASR recombinant protein (amino acids Q926-S1078) was used as the immunogen for the CASR antibody.

Storage

After reconstitution, the CASR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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